- Title
- Back to the Eosinophil: Resolvin Spatiotemporal Regulation
- Creator
- Donovan, Chantal; Barnes, Jessica L.; Kim, Richard Y.
- Relation
- American Journal of Respiratory Cell and Molecular Biology Vol. 69, Issue 6, p. 608-609
- Publisher Link
- http://dx.doi.org/10.1165/rcmb.2023-0261ED
- Publisher
- American Thoracic Society
- Resource Type
- journal article
- Date
- 2023
- Description
- Eosinophils are granulocytes that home to sites of infection and injury, where they can initiate and drive host defense and allergic inflammatory responses. Eosinophil accumulation at different mucosal sites, including the lung and gastrointestinal tract, is also strongly linked with disease pathogenesis (1–3). Levels of blood eosinophils can reflect/predict tissue eosinophil responses and are increasingly being used as biomarkers for phenotyping respiratory diseases, including type 2 (T2)-high severe asthma and eosinophilic chronic obstructive pulmonary disease (4). Through decades of research, knowledge has accumulated regarding how eosinophils differentiate, migrate, undergo activation, and facilitate their own survival (5). However, there is now a growing recognition that eosinophils are not one-trick ponies but rather comprise a heterogeneous population of immune effectors. This opens up a vast range of exciting possibilities relating to their spatiotemporal and functional regulation and the intricacies of their involvement in disease pathogenesis. This framework also raises many new questions about eosinophil biology that warrant exploration to piece together the precise chronology and diversity of eosinophil responses. This could include advanced interrogations of the host signals that recruit and retain different eosinophil subsets, the different cues that govern eosinophil migratory activities (e.g., from the circulation into the lung, and from the lung into the airways), the soluble mediators as well as the intracellular processes that control their phenotypic assignments, and, indeed, the signals that are required for controlled resolution of allergic eosinophilic inflammation.
- Subject
- eosinophil; infection; biomarkers; respiratory diseases
- Identifier
- http://hdl.handle.net/1959.13/1496181
- Identifier
- uon:54156
- Identifier
- ISSN:1044-1549
- Rights
- x
- Language
- eng
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